The sound lateralization test demonstrates slowed processing speed in MS patients with minimal to mild disability, and shows no learning effects in multiple testing sessions over a 1-year period Poster P741/Abstract 420 presented at ECTRIMS 2015
Can the BBB be targeted for treatment of MS? Evidence that IL-6 is actively transported across the BBB in vivo by an IL-6 specific transporter reveals a novel target linked to inflammatory immunit Poster 1869 presented at ECTRIMS-ACTRIMS 2017
Back to the future: nanomedicines in the CNS
Session presented at BNA Christmas Symposium 2017
Nano-engineered LIF to treat multiple sclerosis
Session presented at BIO-Europe 2017
Nanomedicine Award 2017
A NanoBioMed solution for multiple sclerosis
Session presented at BioNanoMed 2017
"LIF" a neuroprotective tolerogenic stem cell growth factor
Past award recipient presentation at GMSI Award Ceremony, ECTRIMS-ACTRIMS 2017
NanoBioMedicine: Nano-formulation of LIF to treat multiple sclerosis, an inflammatory autoimmune disease of the CNS
Session presented at LIF As We Know It: From Basic Science to Clinical Trials 2018
LIFNano brings the healing power of stem cells to treat neurodegenerative disease
Session presented at BioTrinity BioLaunch, 25 April 2018
LIFNano Therapeutics - a first-in-class brain healing company.
Presented at UK BioIndustry Association, 23-24 May 2018
LIF as we know it: from basic science to clinical trials.
Presented at EACR Conference VHIO Barcelona, 28-29 May 2018
LIFNano: a synthetic stem cell to treat MS.
Presented at the British Embassy in Sofia and the UK S&I Network. Sofia Bulgaria 15 March 2019
LIFNano: a synthetic stem cell.
Presented for the showcase exhibit at Accelerating Bio-innovation 2019 meeting University of Cambridge UK and Royalty Pharma USA: Wellcome Genome Campus, 1-3 April 2019
Treating inflammatory disease using synthetic biology.
Presented at BioTrinity 2019, London 1 May 2019
PLGA- nanoparticles containing LIF cross the blood-brain barrier and reverse paralysis in experimental autoimmune encephalomyelitis (EAE).
Presented at NANOMED EUROPE 2019, Braga 17-19 June 2019
Role of purinergic receptor P2X4 in experimental autoimmune encephalomyelitis
Presented at the XIII European Meeting on Glial Cells in Health and Disease, Edinburgh July 2017
Role of IRF5-P2X4R axis in the pathogenesis of experimental autoimmune encephalomyelitis
Presented at the 11th FENS Forum of Neuroscience, Berlin (Germany), July 2018
Functional roles of extracellular vesicles derived from microglia with diverse activation states.
Presented at the XIII European Meeting on Glial Cells in Health and Disease, Edinburgh, UK. July 2017
Microglia-to-neuron shuttling of miRNAs via extracellular vesicles modulate synapse stability and function
Presented at the Jacques Monod Conference Glial Cells at the crossroad of innate immunity and brain function, Roscoff, France. June 2017
Proteomic analysis of ectosomes and exosomes provides new clues on microglia response to ATP
Presented at the 38th Congresso Nazionale della SIF, Rimini, Italy. October 2017
Microglia extracellular vesicles in white and grey matter lesions in multiple sclerosis”
Presented at the CNR IMMUNOLOGY NETWORK – CIN II networking meeting, Rome 2017
Microglia-derived extracellular vesicles regulate the recruitment, proliferation and differentiation of oligodendrocyte precursor cells
Presented at AINI XXVII Congress, Trieste, Italy. May 2019
Multimodal microglia modulation of neuronal function via extracellular vesicles: role of lipids, microRNAs and protein cargoes” (plenary lecture).
Presented at the Portuguese Glial Network, III Symposium, Porto, Portugal 18 May 2018
Multimodal microglia modulation of neuronal function via extracellular vesicles: implications in neuroinflammatory diseases”(plenary lecture).
Presented at Convegno monotemetico SIF Glial Cells and therapeutic perspective, Florence, 29 June 2018.
Microglia-derived Extracellular Vesicles regulate the recruitment, proliferation and differentiation of oligodendrocyte precursor cells
Presented at BBEV - The Biomarkers and Biogenesis of Extracellular Vesicles Workshop, Padoa, Italy. August 2018
Multimodal microglia modulation of neuronal function via EVs: role of microRNAs and protein cargoes.
Presented at BBEV 2018, University of Padua, September 2018
Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles.
Presented at Giornata Sfingolipidi Italia, 5 October 2018
Multimodal microglia modulation of neuronal function via EVs (plenary lecture).
Presented at the More than neuron II edition, Turin. 29th November-1st December 2018
Detrimental and protective action of microglial extracellular vesicles on myelin lesions
Presented at the AINI XXVII Congress, Camogli, Italy. May 2019
Martinez-Lapiscina EH et al. Molecular Imaging of in vivo human Retina by Raman Spectroscopy: basis and MS and Healthy voluntaries profile. Poster presented at ECTRIMS 2015, Barcelona, Spain
Corneal confocal microscopy: a rapid non-invasive surrogate endpoint for axonal loss in multiple sclerosis
Poster created for Weill Cornell Medicine-Qatar and Hamad Medical Corporation and presented in Doha, Qatar
Corneal confocal microscopy detects progressive axonal degeneration in patients with multiple sclerosis
Session presented at Neurological Association of South Africa Congress 2018
Petropoulos IN et al. Corneal confocal microscopy detects progressive axonal degeneration in patients with multiple sclerosis which is progressive. Poster presented at ECTRIMS 2018, Berlin, Germany
Li Y et al. Corneal confocal microscopy: An endpoint for inflammatory cells in patients with multiple sclerosis. Presented at the 143rd American Neurological Association 2018, Atlanta, USA
Petropoulos IN et al. Corneal confocal microscopy: A rapid non-invasive technique to image neurodegeneration. Presented at IMVISUAL symposium, ACTRIMS 2019, Dallas, Texas
Petropoulos IN et al. Corneal confocal microscopy: a rapid non-invasive surrogate endpoint for axonal loss in multiple sclerosis. Poster presented at ECTRIMS 2019, Stockholm, Sweden
Markers of immunosenescence in the peripheral blood of multiple sclerosis subjects compared to healthy controls
Poster 1185 presented at ECTRIMS 2018
Larochelle C. Markers of premature immunosenescence in the peripheral blood of multiple sclerosis subjects vs. healthy controls. Poster presented at ECTRIMS 2019, Stockholm, Sweden
Larochelle C. Immunoscenescence as predictor of MS progression. ECTRIMS-ACTRIMS 2020 Virtual Meeting
Barros C, et al. Targeting S100B reduces demyelination-associated pathogenesis in ex vivo and in vivo models mimicking MS. Poster presented at ECTRIMS 2018, Berlin, Germany
Stern JNH et al. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Sci Transl Med 2014;6:248ra107. doi: 10.1126/scitranslmed.3008879
Willis SN et al. Investigating the antigen specificity of multiple sclerosis central nervous system-derived immunoglobulins. Front Immunol 2015;6:600. doi: 10.3389/fimmu.2015.00600
Harrison DM et al. Leptomeningeal enhancement at 7T in multiple sclerosis: frequency, morphology, and relationship to cortical volume. J Neuroimaging 2017;27:461–8. doi: 10.1111/jon.12444
Ighani M et al. No association between cortical lesions and leptomeningeal enhancement on 7-Tesla MRI in multiple sclerosis. Mult Scler 2020;26:165-176. doi: 10.1177/1352458519876037
Metcalfe SM. LIF and multiple sclerosis: one protein with two healing properties. Mult Scler Relat Disord 2018;20:223–7. doi: 10.1016/j.msard.2018.01.018
Metcalfe SM et al. Neurodegenerative disease: a perspective on cell-based therapy in the new era of cell-free nano-therapy. Curr Pharm Des 2017;23:776–83. doi: 10.2174/1381612822666161206141744
Metcalfe SM et al. Multiple sclerosis and the LIF/IL-6 axis: use of nanotechnology to harness the tolerogenic and reparative properties of LIF. Nanobiomedicine (Rij) 2015;2:5. doi: 10.5772/60622
Rittchen S et al. Myelin repair in vivo is increased by targeting oligodendrocyte precursor cells with nanoparticles encapsulating leukaemia inhibitory factor (LIF). Biomaterials 2015;56:78–85. doi: 10.1016/j.biomaterials.2015.03.044
Metcalf SM et al. Neurodegenerative disease: a perspective on cell-based therapy in the new era of cell-free nanotherapy. Curr Pharm Des 2017;23:776-783. doi: 10.2174/1381612822666161206141744
Kumar G et al. Efficacies of anti-CD20 antibody and Atacicept are differentially impacted by B Cell Maturation Antigen in neuro-autoimmunity. J Immunol 2019; 202 (1 Supplement) 193.9
Zabala A et al. P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis. EMBO Mol Med 2018;10:e8743 doi: 15252/emmm.201708743
Domercq M and Matute C. Targeting P2X4 and P2X7 receptors in multiple sclerosis. Curr Opin Pharmacol 2019;20:119–25. doi: 10.1016/j.coph.2019.03.010
Domercq M et al. Purinergic receptors in multiple sclerosis pathogenesis. Brain Res Bull 2018;pii:S0361–9230:30611–7. doi: 10.1016/j.brainresbull.2018.11.018.
Kitz A et al. AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease. EMBO Rep 2016;17:1169–83. doi: 10.15252/embr.201541905
Pompura SL et al. The PI3K/AKT signalling pathway in regulatory T-cell development, stability and function. J Leukoc Biol 2018;Jan 22. doi: 10.1002/JLB.2MIR0817-349R. [Epub ahead of print]
Kitz A et al. Molecular mechanisms underlying Th1-like Treg generation and function. Cell Mol Life Sci 2017;74:4059–75. doi: 10.1007/s00018-017-2569-y
Drago F et al. ATP modifies the proteome of extracellular vesicles released by microglia and influences their action on astrocytes. Front Pharmacol 2017;8:910. doi: 10.3389/fphar.2017.00910
Prada I. Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations. Acta Neuropathol 2018;135:529–50. doi: 10.1007/s00401-017-1803-x
Verderio C et al. Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles. J Lipid Res 2018;59:1325–40. doi: 10.1194/jlr.R083915
Fumagalli M et al. How to reprogram microglia toward beneficial functions. Glia 2018;66:2531–49. doi: 10.1002/glia.23484
Beaino W et al. Purinergic receptors P2Y12R and P2X7R: potential targets for PET imaging of microglia phenotypes in multiple sclerosis. J Neuroinflammation 2017;14:259. doi: 10.1186/s12974-017-1034-z
Beaino W, et al. PET imaging of P2X 7 R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139. J Neuroinflammation 2020;17:300. doi: 10.1186/s12974-020-01962-7
Hagens MHJ et al. The P2X 7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study. Eur J Nucl Med Mol Imaging 2020;47:379-389. doi: 10.1007/s00259-019-04550-x
Khan A et al. Peripheral neuropathy in patients with multiple sclerosis. PLoS One 2018;13:e0193270. doi: 10.1371/journal.pone.0193270
Petropoulos IN et al. Corneal confocal microscopy: an imaging endpoint for axonal degeneration in multiple sclerosis. Invest Ophthalmol Vis Sci 2017;58:3677–81. doi: 10.1167/iovs.17-22050
Ribeiro AR et al. Frailty-A promising concept to evaluate disease vulnerability. Mech Ageing Dev 2020;187:111217. doi: 10.1016/j.mad.2020.111217
Manca A, et al. Effect of Eccentric Strength Training on Elbow Flexor Spasticity and Muscle Weakness in People With Multiple Sclerosis: Proof-of-Concept Single-System Case Series. Phys Ther 2020;100:1142-1152. doi: 10.1093/ptj/pzaa05
Prada I et al. Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations. Acta Neuropathol. 2018;135:529-550. doi: 10.1007/s00401-017-1803-x
Ramaglia V and Sheikh-Mohamed S. Imaging mass cytometry staining - fresh frozen human brain tissue sections. Bio-protocol 2020;bio-protocol.org/prep266.
Eslami M et al. No BAFF 60-mer, but differential BAFF 60 mer dissociating activities in human serum and CSF fluid. Front Cell Dev Biol 2020. doi:10.3389/fcell.2020.577662