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Department of Pathobiology, University of Pennsylvania, Philadelphia, USA
T cell-based therapy to target B cells within the central nervous system
Despite significant advances in MS research, progressive forms of the disease have remained challenging to treat. Growing evidence suggests that B cells sequestered within the CNS compartment may play pivotal roles in MS and might also be particularly relevant to the pathophysiology of progressive disease. Currently available B-cell-targeting therapies do not deplete B cells that infiltrate or persist within the CNS compartment; therefore, improved strategies are urgently needed to interrogate the causal relationship between meningeal B-cell responses and transition to progressive MS.
Assistant Professor Alvarez aims to investigate whether CAR-T cell therapy can be used to eliminate B cells, which have infiltrated within the meningeal compartments in an experimental mouse model of MS.
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